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Intestinal epithelial potassium channels and CFTR chloride channels activated in ErbB tyrosine kinase inhibitor diarrhea

Diarrhea is a major side effect of ErbB receptor tyrosine kinase inhibitors (TKIs) in cancer chemotherapy. Here, we show that the primary mechanism of ErbB TKI diarrhea is activation of basolateral membrane potassium (K(+)) channels and apical membrane chloride (Cl(–)) channels in intestinal epithel...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Duan, Tianying, Cil, Onur, Thiagarajah, Jay R., Verkman, Alan S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6478423/
https://ncbi.nlm.nih.gov/pubmed/30668547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.126444
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