Inhibition of CFTR-mediated intestinal chloride secretion as potential therapy for bile acid diarrhea

Bile acid diarrhea (BAD) is common with ileal resection, Crohn’s disease, and diarrhea-predominant irritable bowel syndrome. Here, we demonstrate the efficacy of cystic fibrosis transmembrane conductance regulator (CFTR) inhibitor (R)–benzopyrimido-pyrrolo-oxazine-dione-27 (BPO-27) in reducing bile...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:FASEB J
Hlavní autoři: Duan, Tianying, Cil, Onur, Tse, C. Ming, Sarker, Rafiquel, Lin, Ruxian, Donowitz, Mark, Verkman, Alan S.
Médium: Artigo
Jazyk:Inglês
Vydáno: Federation of American Societies for Experimental Biology 2019
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6766649/
https://ncbi.nlm.nih.gov/pubmed/31268738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201901166R
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky