Benzopyrimido-pyrrolo-oxazine-dione CFTR inhibitor (R)-BPO-27 for antisecretory therapy of diarrheas caused by bacterial enterotoxins

Secretory diarrheas caused by bacterial enterotoxins, including cholera and traveler’s diarrhea, remain a major global health problem. Inappropriate activation of the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel occurs in these diarrheas. We previously reported that th...

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Udgivet i:FASEB J
Main Authors: Cil, Onur, Phuan, Puay-Wah, Gillespie, Anne Marie, Lee, Sujin, Tradtrantip, Lukmanee, Yin, Jianyi, Tse, Ming, Zachos, Nicholas C., Lin, Ruxian, Donowitz, Mark, Verkman, Alan S.
Format: Artigo
Sprog:Inglês
Udgivet: Federation of American Societies for Experimental Biology 2017
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5240666/
https://ncbi.nlm.nih.gov/pubmed/27871064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201600891R
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