Absolute Configuration and Biological Properties of Enantiomers of CFTR Inhibitor BPO-27

[Image: see text] We previously reported benzopyrimido-pyrrolo-oxazinedione (BPO) inhibitors of the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel and showed their efficacy in a model of polycystic kidney disease. Here, we separated the enantiomers of lead compound BPO-2...

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Detalhes bibliográficos
Main Authors: Snyder, David S., Tradtrantip, Lukmanee, Battula, Sailaja, Yao, Chenjuan, Phuan, Puay-wah, Fettinger, James C., Kurth, Mark J., Verkman, A. S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2013
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3694630/
https://ncbi.nlm.nih.gov/pubmed/23814642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml400069k
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