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Complement-dependent Cytotoxicity in Neuromyelitis Optica Requires Aquaporin-4 Protein Assembly in Orthogonal Arrays

Neuromyelitis optica (NMO) is an inflammatory demyelinating disease of the central nervous system in which binding of pathogenic autoantibodies (NMO-IgG) to astrocyte aquaporin-4 (AQP4) causes complement-dependent cytotoxicity (CDC) and inflammation. We previously reported a wide range of binding af...

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Autors principals: Phuan, Puay-Wah, Ratelade, Julien, Rossi, Andrea, Tradtrantip, Lukmanee, Verkman, A. S.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3340190/
https://ncbi.nlm.nih.gov/pubmed/22393049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.344325
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