CFTR Activator Increases Intestinal Fluid Secretion and Normalizes Stool Output in a Mouse Model of Constipation

BACKGROUND & AIMS: Constipation is a common clinical problem that negatively impacts quality of life and is associated with significant health care costs. Activation of the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel is the primary pathway that drives fluid secret...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Cell Mol Gastroenterol Hepatol
Egile Nagusiak: Cil, Onur, Phuan, Puay-Wah, Lee, Sujin, Tan, Joseph, Haggie, Peter M., Levin, Marc H., Sun, Liang, Thiagarajah, Jay R., Ma, Tonghui, Verkman, Alan S.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Elsevier 2016
Gaiak:
Original Research
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4844355/
https://ncbi.nlm.nih.gov/pubmed/27127798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jcmgh.2015.12.010
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