CFTR Activator Increases Intestinal Fluid Secretion and Normalizes Stool Output in a Mouse Model of Constipation

BACKGROUND & AIMS: Constipation is a common clinical problem that negatively impacts quality of life and is associated with significant health care costs. Activation of the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel is the primary pathway that drives fluid secret...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cell Mol Gastroenterol Hepatol
Prif Awduron: Cil, Onur, Phuan, Puay-Wah, Lee, Sujin, Tan, Joseph, Haggie, Peter M., Levin, Marc H., Sun, Liang, Thiagarajah, Jay R., Ma, Tonghui, Verkman, Alan S.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Elsevier 2016
Pynciau:
Original Research
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4844355/
https://ncbi.nlm.nih.gov/pubmed/27127798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jcmgh.2015.12.010
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