Phenylquinoxalinone CFTR activator as potential prosecretory therapy for constipation

Constipation is a common condition for which current treatments can have limited efficacy. By high-throughput screening, we recently identified a phenylquinoxalinone activator of the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel that stimulated intestinal fluid secretio...

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Udgivet i:Transl Res
Main Authors: CIL, ONUR, PHUAN, PUAY-WAH, SON, JUNG-HO, ZHU, JIE S., KU, COLTON K., TABIB, NILOUFAR AKHAVAN, TEUTHORN, ANDREW P., FERRERA, LORETTA, ZACHOS, NICHOLAS C., LIN, RUXIAN, GALIETTA, LUIS J. V., DONOWITZ, MARK, KURTH, MARK J., VERKMAN, ALAN S.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5453637/
https://ncbi.nlm.nih.gov/pubmed/27815136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.trsl.2016.10.003
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