Phenylquinoxalinone CFTR activator as potential prosecretory therapy for constipation

Constipation is a common condition for which current treatments can have limited efficacy. By high-throughput screening, we recently identified a phenylquinoxalinone activator of the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel that stimulated intestinal fluid secretio...

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Publicado no:Transl Res
Main Authors: CIL, ONUR, PHUAN, PUAY-WAH, SON, JUNG-HO, ZHU, JIE S., KU, COLTON K., TABIB, NILOUFAR AKHAVAN, TEUTHORN, ANDREW P., FERRERA, LORETTA, ZACHOS, NICHOLAS C., LIN, RUXIAN, GALIETTA, LUIS J. V., DONOWITZ, MARK, KURTH, MARK J., VERKMAN, ALAN S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5453637/
https://ncbi.nlm.nih.gov/pubmed/27815136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.trsl.2016.10.003
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