Phenylquinoxalinone CFTR activator as potential prosecretory therapy for constipation

Constipation is a common condition for which current treatments can have limited efficacy. By high-throughput screening, we recently identified a phenylquinoxalinone activator of the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel that stimulated intestinal fluid secretio...

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Enregistré dans:
Détails bibliographiques
Publié dans:Transl Res
Auteurs principaux: CIL, ONUR, PHUAN, PUAY-WAH, SON, JUNG-HO, ZHU, JIE S., KU, COLTON K., TABIB, NILOUFAR AKHAVAN, TEUTHORN, ANDREW P., FERRERA, LORETTA, ZACHOS, NICHOLAS C., LIN, RUXIAN, GALIETTA, LUIS J. V., DONOWITZ, MARK, KURTH, MARK J., VERKMAN, ALAN S.
Format: Artigo
Langue:Inglês
Publié: 2016
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5453637/
https://ncbi.nlm.nih.gov/pubmed/27815136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.trsl.2016.10.003
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