CFTR Activator Increases Intestinal Fluid Secretion and Normalizes Stool Output in a Mouse Model of Constipation

BACKGROUND & AIMS: Constipation is a common clinical problem that negatively impacts quality of life and is associated with significant health care costs. Activation of the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel is the primary pathway that drives fluid secret...

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Vydáno v:Cell Mol Gastroenterol Hepatol
Hlavní autoři: Cil, Onur, Phuan, Puay-Wah, Lee, Sujin, Tan, Joseph, Haggie, Peter M., Levin, Marc H., Sun, Liang, Thiagarajah, Jay R., Ma, Tonghui, Verkman, Alan S.
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2016
Témata:
Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4844355/
https://ncbi.nlm.nih.gov/pubmed/27127798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jcmgh.2015.12.010
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