SLC26A3 inhibitor identified in small molecule screen blocks colonic fluid absorption and reduces constipation

SLC26A3 (downregulated in adenoma; DRA) is a Cl(–)/anion exchanger expressed in the luminal membrane of intestinal epithelial cells, where it facilitates electroneutral NaCl absorption. SLC26A3 loss of function in humans or mice causes chloride-losing diarrhea. Here, we identified slc26a3 inhibitors...

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Pubblicato in:JCI Insight
Autori principali: Haggie, Peter M., Cil, Onur, Lee, Sujin, Tan, Joseph-Anthony, Rivera, Amber A., Phuan, Puay-Wah, Verkman, Alan S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2018
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6124422/
https://ncbi.nlm.nih.gov/pubmed/30046015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.121370
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