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SLC26A6-selective inhibitor identified in a small-molecule screen blocks fluid absorption in small intestine
SLC26A6 (also known as putative anion transporter 1 [PAT1]) is a Cl(–)/HCO(3)(–) exchanger expressed at the luminal membrane of enterocytes where it facilitates intestinal Cl(–) and fluid absorption. Here, high-throughput screening of 50,000 synthetic small molecules in cells expressing PAT1 and a h...
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| Vydáno v: | JCI Insight |
|---|---|
| Hlavní autoři: | , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
American Society for Clinical Investigation
2021
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8262356/ https://ncbi.nlm.nih.gov/pubmed/34100381 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.147699 |
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