Intestinal epithelial potassium channels and CFTR chloride channels activated in ErbB tyrosine kinase inhibitor diarrhea

Diarrhea is a major side effect of ErbB receptor tyrosine kinase inhibitors (TKIs) in cancer chemotherapy. Here, we show that the primary mechanism of ErbB TKI diarrhea is activation of basolateral membrane potassium (K(+)) channels and apical membrane chloride (Cl(–)) channels in intestinal epithel...

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Udgivet i:JCI Insight
Main Authors: Duan, Tianying, Cil, Onur, Thiagarajah, Jay R., Verkman, Alan S.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6478423/
https://ncbi.nlm.nih.gov/pubmed/30668547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.126444
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