Mitochondrial Aging Defects Emerge in Directly Reprogrammed Human Neurons due to Their Metabolic Profile

Mitochondria are a major target for aging and are instrumental in the age-dependent deterioration of the human brain, but studying mitochondria in aging human neurons has been challenging. Direct fibroblast-to-induced neuron (iN) conversion yields functional neurons that retain important signs of ag...

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Bibliografske podrobnosti
izdano v:Cell Rep
Main Authors: Kim, Yongsung, Zheng, Xinde, Ansari, Zoya, Bunnell, Mark C., Herdy, Joseph R., Traxler, Larissa, Lee, Hyungjun, Paquola, Apua C.M., Blithikioti, Chrysanthi, Ku, Manching, Schlachetzki, Johannes C.M., Winkler, Jürgen, Edenhofer, Frank, Glass, Christopher K., Paucar, Andres A., Jaeger, Baptiste N., Pham, Son, Boyer, Leah, Campbell, Benjamin C., Hunter, Tony, Mertens, Jerome, Gage, Fred H.
Format: Artigo
Jezik:Inglês
Izdano: 2018
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6478017/
https://ncbi.nlm.nih.gov/pubmed/29847787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.04.105
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