Directly Reprogrammed Human Neurons Retain Aging-Associated Transcriptomic Signatures and Reveal Age-Related Nucleocytoplasmic Defects

Aging is a major risk factor for many human diseases, and in vitro generation of human neurons is an attractive approach for modeling aging-related brain disorders. However, modeling aging in differentiated human neurons has proved challenging. We generated neurons from human donors across a broad r...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:Cell Stem Cell
Κύριοι συγγραφείς: Mertens, Jerome, Paquola, Apuã C.M., Ku, Manching, Hatch, Emily, Böhnke, Lena, Ladjevardi, Shauheen, McGrath, Sean, Campbell, Benjamin, Lee, Hyungjun, Herdy, Joseph R., Gonçalves, J. Tiago, Toda, Tomohisa, Kim, Yongsung, Winkler, Jürgen, Yao, Jun, Hetzer, Martin W., Gage, Fred H.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: 2015
Θέματα:
Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5929130/
https://ncbi.nlm.nih.gov/pubmed/26456686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2015.09.001
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