Directly Reprogrammed Human Neurons Retain Aging-Associated Transcriptomic Signatures and Reveal Age-Related Nucleocytoplasmic Defects

Aging is a major risk factor for many human diseases, and in vitro generation of human neurons is an attractive approach for modeling aging-related brain disorders. However, modeling aging in differentiated human neurons has proved challenging. We generated neurons from human donors across a broad r...

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Vydáno v:Cell Stem Cell
Hlavní autoři: Mertens, Jerome, Paquola, Apuã C.M., Ku, Manching, Hatch, Emily, Böhnke, Lena, Ladjevardi, Shauheen, McGrath, Sean, Campbell, Benjamin, Lee, Hyungjun, Herdy, Joseph R., Gonçalves, J. Tiago, Toda, Tomohisa, Kim, Yongsung, Winkler, Jürgen, Yao, Jun, Hetzer, Martin W., Gage, Fred H.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5929130/
https://ncbi.nlm.nih.gov/pubmed/26456686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2015.09.001
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