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Directly Reprogrammed Human Neurons Retain Aging-Associated Transcriptomic Signatures and Reveal Age-Related Nucleocytoplasmic Defects
Aging is a major risk factor for many human diseases, and in vitro generation of human neurons is an attractive approach for modeling aging-related brain disorders. However, modeling aging in differentiated human neurons has proved challenging. We generated neurons from human donors across a broad r...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | Cell Stem Cell |
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| Κύριοι συγγραφείς: | , , , , , , , , , , , , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2015
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5929130/ https://ncbi.nlm.nih.gov/pubmed/26456686 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2015.09.001 |
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