Directly Reprogrammed Human Neurons Retain Aging-Associated Transcriptomic Signatures and Reveal Age-Related Nucleocytoplasmic Defects

Aging is a major risk factor for many human diseases, and in vitro generation of human neurons is an attractive approach for modeling aging-related brain disorders. However, modeling aging in differentiated human neurons has proved challenging. We generated neurons from human donors across a broad r...

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Detalhes bibliográficos
Publicado no:Cell Stem Cell
Main Authors: Mertens, Jerome, Paquola, Apuã C.M., Ku, Manching, Hatch, Emily, Böhnke, Lena, Ladjevardi, Shauheen, McGrath, Sean, Campbell, Benjamin, Lee, Hyungjun, Herdy, Joseph R., Gonçalves, J. Tiago, Toda, Tomohisa, Kim, Yongsung, Winkler, Jürgen, Yao, Jun, Hetzer, Martin W., Gage, Fred H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5929130/
https://ncbi.nlm.nih.gov/pubmed/26456686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2015.09.001
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