Mitochondrial Aging Defects Emerge in Directly Reprogrammed Human Neurons due to Their Metabolic Profile

Mitochondria are a major target for aging and are instrumental in the age-dependent deterioration of the human brain, but studying mitochondria in aging human neurons has been challenging. Direct fibroblast-to-induced neuron (iN) conversion yields functional neurons that retain important signs of ag...

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Publicado no:Cell Rep
Main Authors: Kim, Yongsung, Zheng, Xinde, Ansari, Zoya, Bunnell, Mark C., Herdy, Joseph R., Traxler, Larissa, Lee, Hyungjun, Paquola, Apua C.M., Blithikioti, Chrysanthi, Ku, Manching, Schlachetzki, Johannes C.M., Winkler, Jürgen, Edenhofer, Frank, Glass, Christopher K., Paucar, Andres A., Jaeger, Baptiste N., Pham, Son, Boyer, Leah, Campbell, Benjamin C., Hunter, Tony, Mertens, Jerome, Gage, Fred H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6478017/
https://ncbi.nlm.nih.gov/pubmed/29847787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.04.105
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