Pathological priming causes developmental gene network heterochronicity in autism patient-derived neurons

Autism spectrum disorder (ASD) is thought to emerge during early cortical development. However, the exact developmental stages and associated molecular networks that prime disease propensity are elusive. To profile early neurodevelopmental alterations in ASD with macrocephaly, we monitored patient-d...

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Detalhes bibliográficos
Publicado no:Nat Neurosci
Main Authors: Schafer, Simon T., Paquola, Apua C.M., Stern, Shani, Gosselin, David, Ku, Manching, Pena, Monique, Kuret, Thomas J.M., Liyanage, Marvin, Mansour, Abed AlFatah, Jaeger, Baptiste N., Marchetto, Maria C., Glass, Christopher K., Mertens, Jerome, Gage, Fred H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6402576/
https://ncbi.nlm.nih.gov/pubmed/30617258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41593-018-0295-x
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