Efficient Generation of CA3 Neurons from Human Pluripotent Stem Cells Enables Modeling of Hippocampal Connectivity In Vitro

Despite widespread interest in using human induced pluripotent stem cells (hiPSCs) in neurological disease modeling, a suitable model system to study human neuronal connectivity is lacking. Here, we report a comprehensive and efficient differentiation paradigm for hiPSCs that generate multiple CA3 p...

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Detalhes bibliográficos
Publicado no:Cell Stem Cell
Main Authors: Sarkar, Anindita, Mei, Arianna, Paquola, Apua C.M., Stern, Shani, Bardy, Cedric, Klug, Jason R., Kim, Stacy, Neshat, Neda, Kim, Hyung Joon, Ku, Manching, Shokhirev, Maxim N., Adamowicz, David H., Marchetto, Maria C., Jappelli, Roberto, Erwin, Jennifer A., Padmanabhan, Krishnan, Shtrahman, Matthew, Jin, Xin, Gage, Fred H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6345574/
https://ncbi.nlm.nih.gov/pubmed/29727680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2018.04.009
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