Pathological priming causes developmental gene network heterochronicity in autism patient-derived neurons

Autism spectrum disorder (ASD) is thought to emerge during early cortical development. However, the exact developmental stages and associated molecular networks that prime disease propensity are elusive. To profile early neurodevelopmental alterations in ASD with macrocephaly, we monitored patient-d...

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Vydáno v:Nat Neurosci
Hlavní autoři: Schafer, Simon T., Paquola, Apua C.M., Stern, Shani, Gosselin, David, Ku, Manching, Pena, Monique, Kuret, Thomas J.M., Liyanage, Marvin, Mansour, Abed AlFatah, Jaeger, Baptiste N., Marchetto, Maria C., Glass, Christopher K., Mertens, Jerome, Gage, Fred H.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6402576/
https://ncbi.nlm.nih.gov/pubmed/30617258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41593-018-0295-x
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