Mitochondrial Aging Defects Emerge in Directly Reprogrammed Human Neurons due to Their Metabolic Profile

Mitochondria are a major target for aging and are instrumental in the age-dependent deterioration of the human brain, but studying mitochondria in aging human neurons has been challenging. Direct fibroblast-to-induced neuron (iN) conversion yields functional neurons that retain important signs of ag...

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Publicado en:Cell Rep
Autores principales: Kim, Yongsung, Zheng, Xinde, Ansari, Zoya, Bunnell, Mark C., Herdy, Joseph R., Traxler, Larissa, Lee, Hyungjun, Paquola, Apua C.M., Blithikioti, Chrysanthi, Ku, Manching, Schlachetzki, Johannes C.M., Winkler, Jürgen, Edenhofer, Frank, Glass, Christopher K., Paucar, Andres A., Jaeger, Baptiste N., Pham, Son, Boyer, Leah, Campbell, Benjamin C., Hunter, Tony, Mertens, Jerome, Gage, Fred H.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6478017/
https://ncbi.nlm.nih.gov/pubmed/29847787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.04.105
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