THER-28. A CK1α ACTIVATOR PENETRATES THE BRAIN, AND SHOWS EFFICACY AGAINST DRUG-RESISTANT METASTATIC MEDULLOBLASTOMA

Although most children with medulloblastoma (MB) are cured of their disease, SONIC HEDGEHOG (SHH) subgroup MB driven by TRP53 mutations is essentially lethal. Casein Kinase 1α (CK1α) phosphorylates and destabilizes GLI transcription factors, thereby inhibiting the key effectors of SHH signaling. We...

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Опубликовано в: :Neuro Oncol
Главные авторы: Rodriguez, Jezabel, Li, Bin, Long, Jun, Shen, Chen, Yang, Fan, Orthon, Darren, Collins, Sara, Kasahara, Noriyuki, Ayad, Nagi, McCrea, Heather, Roussel, Martine, Weiss, William, Capobianco, Anthony, Robbins, David
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2019
Предметы:
Translational Therapeutics
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6477352/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz036.233
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