THER-28. A CK1α ACTIVATOR PENETRATES THE BRAIN, AND SHOWS EFFICACY AGAINST DRUG-RESISTANT METASTATIC MEDULLOBLASTOMA

Although most children with medulloblastoma (MB) are cured of their disease, SONIC HEDGEHOG (SHH) subgroup MB driven by TRP53 mutations is essentially lethal. Casein Kinase 1α (CK1α) phosphorylates and destabilizes GLI transcription factors, thereby inhibiting the key effectors of SHH signaling. We...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Rodriguez, Jezabel, Li, Bin, Long, Jun, Shen, Chen, Yang, Fan, Orthon, Darren, Collins, Sara, Kasahara, Noriyuki, Ayad, Nagi, McCrea, Heather, Roussel, Martine, Weiss, William, Capobianco, Anthony, Robbins, David
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Translational Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6477352/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz036.233
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