DDIS-11. A CK1a ACTIVATOR PENETRATES THE BRAIN, AND SHOWS EFFICACY AGAINST DRUG-RESISTANT METASTATIC MEDULLOBLASTOMA

Although most children with medulloblastoma (MB) are cured of their disease, SONIC HEDGEHOG (SHH) subgroup MB driven by TRP53 mutations is essentially lethal. Casein Kinase 1a (CK1a phosphorylates and destabilizes GLI transcription factors, thereby inhibiting the key effectors of SHH signaling. We t...

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Bibliografiske detaljer
Udgivet i:Neuro Oncol
Main Authors: Rodriguez Blanco, Jezabel, Li, Bin, Long, Jun, Orthon, Darren, Ayad, Nagi, MaCrea, Heather, Roussel, Martine, Weiss, William, Capobianco, Anthony, Robbins, David
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2018
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Abstracts
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6216558/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy148.290
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