DDIS-11. A CK1a ACTIVATOR PENETRATES THE BRAIN, AND SHOWS EFFICACY AGAINST DRUG-RESISTANT METASTATIC MEDULLOBLASTOMA

Although most children with medulloblastoma (MB) are cured of their disease, SONIC HEDGEHOG (SHH) subgroup MB driven by TRP53 mutations is essentially lethal. Casein Kinase 1a (CK1a phosphorylates and destabilizes GLI transcription factors, thereby inhibiting the key effectors of SHH signaling. We t...

Cijeli opis

Spremljeno u:
Bibliografski detalji
Izdano u:Neuro Oncol
Glavni autori: Rodriguez Blanco, Jezabel, Li, Bin, Long, Jun, Orthon, Darren, Ayad, Nagi, MaCrea, Heather, Roussel, Martine, Weiss, William, Capobianco, Anthony, Robbins, David
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2018
Teme:
Abstracts
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6216558/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy148.290
Oznake: Dodaj oznaku
Bez oznaka, Budi prvi tko označuje ovaj zapis!

Similar Items