THER-28. A CK1α ACTIVATOR PENETRATES THE BRAIN, AND SHOWS EFFICACY AGAINST DRUG-RESISTANT METASTATIC MEDULLOBLASTOMA

Although most children with medulloblastoma (MB) are cured of their disease, SONIC HEDGEHOG (SHH) subgroup MB driven by TRP53 mutations is essentially lethal. Casein Kinase 1α (CK1α) phosphorylates and destabilizes GLI transcription factors, thereby inhibiting the key effectors of SHH signaling. We...

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Dettagli Bibliografici
Pubblicato in:Neuro Oncol
Autori principali: Rodriguez, Jezabel, Li, Bin, Long, Jun, Shen, Chen, Yang, Fan, Orthon, Darren, Collins, Sara, Kasahara, Noriyuki, Ayad, Nagi, McCrea, Heather, Roussel, Martine, Weiss, William, Capobianco, Anthony, Robbins, David
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2019
Soggetti:
Translational Therapeutics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6477352/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz036.233
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