THER-28. A CK1α ACTIVATOR PENETRATES THE BRAIN, AND SHOWS EFFICACY AGAINST DRUG-RESISTANT METASTATIC MEDULLOBLASTOMA

Although most children with medulloblastoma (MB) are cured of their disease, SONIC HEDGEHOG (SHH) subgroup MB driven by TRP53 mutations is essentially lethal. Casein Kinase 1α (CK1α) phosphorylates and destabilizes GLI transcription factors, thereby inhibiting the key effectors of SHH signaling. We...

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Dades bibliogràfiques
Publicat a:Neuro Oncol
Autors principals: Rodriguez, Jezabel, Li, Bin, Long, Jun, Shen, Chen, Yang, Fan, Orthon, Darren, Collins, Sara, Kasahara, Noriyuki, Ayad, Nagi, McCrea, Heather, Roussel, Martine, Weiss, William, Capobianco, Anthony, Robbins, David
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2019
Matèries:
Translational Therapeutics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6477352/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz036.233
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