THER-30. COMBINATION TOCA 511 & 5-FC SIGNIFICANTLY EXTENDS SURVIVAL IN A MURINE ORTHOTOPIC MODEL OF INTRACEREBELLAR MEDULLOBLASTOMA

Toca 511, a clinical-stage tumor-selective retroviral replicating vector (RRV) encoding an optimized yeast cytosine deaminase (CD) prodrug activator gene, in combination with Toca FC (extended-release 5-fluorocytosine (5-FC)), produces 5-fluorouracil (5-FU) within infected cancer cells, which in pre...

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Bibliografische gegevens
Gepubliceerd in:Neuro Oncol
Hoofdauteurs: Richardson, Angela, Collins, Sara, Inagaki, Akhito, Armstrong, Valerie, Roussel, Martine, Robbins, David, Ayad, Nagy, Jolly, Douglas, Kasahara, Noriyuki
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2019
Onderwerpen:
Translational Therapeutics
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6477222/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz036.235
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