Structural Dynamics of the Activation of Elongation Factor 2 Kinase by Ca(2+)-Calmodulin

Eukaryotic elongation factor 2 kinase (eEF-2K), the only known calmodulin (CaM) activated α–kinase, phosphorylates eukaryotic elongation factor 2 (eEF-2) on a specific threonine (Thr-56) diminishing its affinity for the ribosome and reducing the rate of nascent chain elongation during translation. D...

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Publicat a:J Mol Biol
Autors principals: Will, Nathan, Lee, Kwangwoon, Hajredini, Fatlum, Giles, David H., Abzalimov, Rinat R., Clarkson, Michael, Dalby, Kevin N., Ghose, Ranajeet
Format: Artigo
Idioma:Inglês
Publicat: 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6474356/
https://ncbi.nlm.nih.gov/pubmed/29800565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2018.05.033
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