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The role of calcium in the interaction between calmodulin and a minimal functional construct of eukaryotic elongation factor 2 kinase

Eukaryotic elongation factor 2 kinase (eEF‐2K) regulates protein synthesis by phosphorylating eukaryotic elongation factor 2 (eEF‐2), thereby reducing its affinity for the ribosome and suppressing global translational elongation rates. eEF‐2K is regulated by calmodulin (CaM) through a mechanism that...

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Detalhes bibliográficos
Publicado no:Protein Sci
Main Authors: Lee, Kwangwoon, Kumar, Eric A., Dalby, Kevin N., Ghose, Ranajeet
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley & Sons, Inc. 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6863733/
https://ncbi.nlm.nih.gov/pubmed/31626716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.3753
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