Solution Structure of the Carboxy-terminal Tandem Repeat Domain of Eukaryotic Elongation Factor 2 Kinase and its Role in Substrate Recognition

Eukaryotic elongation factor 2 kinase (eEF-2K), an atypical calmodulin-activated protein kinase, regulates translational elongation by phosphorylating its substrate, eukaryotic elongation factor 2 (eEF-2), thereby reducing its affinity for the ribosome. The activation and activity of eEF-2K are crit...

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Publicado en:J Mol Biol
Autores principales: Piserchio, Andrea, Will, Nathan, Giles, David H., Hajredini, Fatlum, Dalby, Kevin N., Ghose, Ranajeet
Formato: Artigo
Lenguaje:Inglês
Publicado: 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6599559/
https://ncbi.nlm.nih.gov/pubmed/31108082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2019.05.019
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