RSK2 contributes to myogenic vasoconstriction of resistance arteries by activating smooth muscle myosin and the Na(+)/H(+) exchanger

Smooth muscle contraction is triggered when Ca(2+)/calmodulin-dependent myosin light chain kinase (MLCK) phosphorylates the regulatory light chain of myosin (RLC(20)). However, blood vessels from Mlck-deficient mouse embryos retain the ability to contract, suggesting the existence of additional regu...

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Publicat a:Sci Signal
Autors principals: Artamonov, Mykhaylo V., Sonkusare, Swapnil K., Good, Miranda E., Momotani, Ko, Eto, Masumi, Isakson, Brant E., Le, Thu H., Cope, Eric L., Derewenda, Zygmunt S., Derewenda, Urszula, Somlyo, Avril V.
Format: Artigo
Idioma:Inglês
Publicat: 2018
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6474246/
https://ncbi.nlm.nih.gov/pubmed/30377223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aar3924
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