On the mechanism of autoinhibition of the RhoA-specific nucleotide exchange factor PDZRhoGEF

BACKGROUND: The Dbl-family of guanine nucleotide exchange factors (GEFs) activate the cytosolic GTPases of the Rho family by enhancing the rate of exchange of GTP for GDP on the cognate GTPase. This catalytic activity resides in the DH (Dbl-homology) domain, but typically GEFs are multidomain protei...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Zheng, Meiying, Cierpicki, Tomasz, Momotani, Ko, Artamonov, Mykhaylo V, Derewenda, Urszula, Bushweller, John H, Somlyo, Avril V, Derewenda, Zygmunt S
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: BioMed Central 2009
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2695464/
https://ncbi.nlm.nih.gov/pubmed/19460155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1472-6807-9-36
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