p63RhoGEF Couples G(αq/11)-mediated Signaling to Ca(2+) Sensitization of Vascular Smooth Muscle Contractility

RATIONALE: In normal and diseased vascular smooth muscle (SM), the RhoA pathway, which is activated by multiple agonists through G protein-coupled receptors (GPCRs), plays a central role in regulating basal tone and peripheral resistance. This occurs through inhibition of myosin light chain phosphat...

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Main Authors: Momotani, Ko, Artamonov, Mykhaylo V., Utepbergenov, Darkhan, Derewenda, Urszula, Derewenda, Zygmunt S., Somlyo, Avril V.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2011
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3211138/
https://ncbi.nlm.nih.gov/pubmed/21885830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.111.248898
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