Agonist-induced Ca(2+) Sensitization in Smooth Muscle: REDUNDANCY OF RHO GUANINE NUCLEOTIDE EXCHANGE FACTORS (RhoGEFs) AND RESPONSE KINETICS, A CAGED COMPOUND STUDY

Many agonists, acting through G-protein-coupled receptors and Gα subunits of the heterotrimeric G-proteins, induce contraction of smooth muscle through an increase of [Ca(2+)](i) as well as activation of the RhoA/RhoA-activated kinase pathway that amplifies the contractile force, a phenomenon known...

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Detalhes bibliográficos
Main Authors: Artamonov, Mykhaylo V., Momotani, Ko, Stevenson, Andra, Trentham, David R., Derewenda, Urszula, Derewenda, Zygmunt S., Read, Paul W., Gutkind, J. Silvio, Somlyo, Avril V.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Molecular Biophysics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3837142/
https://ncbi.nlm.nih.gov/pubmed/24106280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.514596
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