Insights into the Molecular Activation Mechanism of the RhoA-specific Guanine Nucleotide Exchange Factor, PDZRhoGEF

PDZRhoGEF (PRG) belongs to a small family of RhoA-specific nucleotide exchange factors that mediates signaling through select G-protein-coupled receptors via Gα(12/13) and activates RhoA by catalyzing the exchange of GDP to GTP. PRG is a multidomain protein composed of PDZ, regulators of G-protein s...

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Detalhes bibliográficos
Main Authors: Bielnicki, Jakub A., Shkumatov, Alexander V., Derewenda, Urszula, Somlyo, Avril V., Svergun, Dmitri I., Derewenda, Zygmunt S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3186380/
https://ncbi.nlm.nih.gov/pubmed/21816819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.270918
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