On the mechanism of autoinhibition of the RhoA-specific nucleotide exchange factor PDZRhoGEF

BACKGROUND: The Dbl-family of guanine nucleotide exchange factors (GEFs) activate the cytosolic GTPases of the Rho family by enhancing the rate of exchange of GTP for GDP on the cognate GTPase. This catalytic activity resides in the DH (Dbl-homology) domain, but typically GEFs are multidomain protei...

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Hauptverfasser: Zheng, Meiying, Cierpicki, Tomasz, Momotani, Ko, Artamonov, Mykhaylo V, Derewenda, Urszula, Bushweller, John H, Somlyo, Avril V, Derewenda, Zygmunt S
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2009
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2695464/
https://ncbi.nlm.nih.gov/pubmed/19460155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1472-6807-9-36
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