Identification of quercitrin as an inhibitor of the p90 S6 ribosomal kinase (RSK): structure of its complex with the N-terminal domain of RSK2 at 1.8 Å resolution

Members of the RSK family of kinases constitute attractive targets for drug design, but a lack of structural information regarding the mechanism of selective inhibitors impedes progress in this field. The crystal structure of the N-terminal kinase domain (residues 45–346) of mouse RSK2, or RSK2(NTKD...

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Главные авторы: Derewenda, Urszula, Artamonov, Mykhaylo, Szukalska, Gabriela, Utepbergenov, Darkhan, Olekhnovich, Natalya, Parikh, Hardik I., Kellogg, Glen E., Somlyo, Avril V., Derewenda, Zygmunt S.
Формат: Artigo
Язык:Inglês
Опубликовано: International Union of Crystallography 2013
Предметы:
Research Papers
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3565440/
https://ncbi.nlm.nih.gov/pubmed/23385462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S0907444912045520
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