Identification of quercitrin as an inhibitor of the p90 S6 ribosomal kinase (RSK): structure of its complex with the N-terminal domain of RSK2 at 1.8 Å resolution

Members of the RSK family of kinases constitute attractive targets for drug design, but a lack of structural information regarding the mechanism of selective inhibitors impedes progress in this field. The crystal structure of the N-terminal kinase domain (residues 45–346) of mouse RSK2, or RSK2(NTKD...

Descripció completa

Guardat en:
Dades bibliogràfiques
Autors principals: Derewenda, Urszula, Artamonov, Mykhaylo, Szukalska, Gabriela, Utepbergenov, Darkhan, Olekhnovich, Natalya, Parikh, Hardik I., Kellogg, Glen E., Somlyo, Avril V., Derewenda, Zygmunt S.
Format: Artigo
Idioma:Inglês
Publicat: International Union of Crystallography 2013
Matèries:
Research Papers
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3565440/
https://ncbi.nlm.nih.gov/pubmed/23385462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S0907444912045520
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars