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The unusual mechanism of inhibition of the p90 ribosomal S6 kinase (RSK) by flavonol rhamnosides

All known protein kinases share a bilobal kinase domain with well conserved structural elements. Because of significant structural similarities of nucleotide binding pocket, the development of highly selective kinase inhibitors is a very challenging task. Flavonols, naturally occurring plant metabol...

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Autori principali: Utepbergenov, Darkhan, Derewenda, Zygmunt S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3683371/
https://ncbi.nlm.nih.gov/pubmed/23541530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbapap.2013.03.018
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