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Distinct Pathways Affected by Menin versus MLL1/MLL2 in MLL-rearranged Acute Myeloid Leukemia
Disrupting protein-protein interaction for molecularly targeted cancer therapeutics can be a challenging but promising strategy. Compounds that disrupt the interaction between Menin, a chromatin-binding protein, and oncogenic MLL fusion proteins (FPs) have shown significant promise in pre-clinical m...
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| 出版年: | Exp Hematol |
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| 主要な著者: | , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2018
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6472707/ https://ncbi.nlm.nih.gov/pubmed/30315824 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exphem.2018.10.001 |
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