Distinct Pathways Affected by Menin versus MLL1/MLL2 in MLL-rearranged Acute Myeloid Leukemia

Disrupting protein-protein interaction for molecularly targeted cancer therapeutics can be a challenging but promising strategy. Compounds that disrupt the interaction between Menin, a chromatin-binding protein, and oncogenic MLL fusion proteins (FPs) have shown significant promise in pre-clinical m...

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Udgivet i:Exp Hematol
Main Authors: Chen, Yufei, Jones, Kenneth L., Anastassiadis, Konstantinos, Kranz, Andrea, Stewart, A. Francis, Grembecka, Jolanta, Meyerson, Matthew, Ernst, Patricia
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6472707/
https://ncbi.nlm.nih.gov/pubmed/30315824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exphem.2018.10.001
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