MLL2, not MLL1, Plays a Major Role in Sustaining MLL-rearranged Acute Myeloid Leukemia

The MLL1 histone methyltransferase gene undergoes many distinct chromosomal rearrangements to yield poor-prognosis leukemia. The remaining wild-type allele is most commonly, but not always, retained. To what extent the wild-type allele contributes to leukemogenesis is unclear. Here we show using rig...

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Detalhes bibliográficos
Publicado no:Cancer Cell
Main Authors: Chen, Yufei, Anastassiadis, Konstantinos, Kranz, Andrea, Stewart, A. Francis, Arndt, Kathrin, Waskow, Claudia, Yokoyama, Akihiko, Jones, Kenneth, Neff, Tobias, Lee, Yoo, Ernst, Patricia
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5598468/
https://ncbi.nlm.nih.gov/pubmed/28609655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2017.05.002
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