Chargement en cours...
Physiologically-Based Pharmacokinetic Modeling for Drug-Drug Interactions of Procainamide and N-Acetylprocainamide with Cimetidine, an Inhibitor of rOCT2 and rMATE1, in Rats
Previous observations demonstrated that cimetidine decreased the clearance of procainamide (PA) and/or N-acetylprocainamide (NAPA; the primary metabolite of PA) resulting in the increased systemic exposure and the decrease of urinary excretion. Despite an abundance of in vitro and in vivo data regar...
Enregistré dans:
| Publié dans: | Pharmaceutics |
|---|---|
| Auteurs principaux: | , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
MDPI
2019
|
| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6470842/ https://ncbi.nlm.nih.gov/pubmed/30845766 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics11030108 |
| Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|