Physiologically-Based Pharmacokinetic Modeling for Drug-Drug Interactions of Procainamide and N-Acetylprocainamide with Cimetidine, an Inhibitor of rOCT2 and rMATE1, in Rats

Previous observations demonstrated that cimetidine decreased the clearance of procainamide (PA) and/or N-acetylprocainamide (NAPA; the primary metabolite of PA) resulting in the increased systemic exposure and the decrease of urinary excretion. Despite an abundance of in vitro and in vivo data regar...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:Pharmaceutics
Autores principales: Jeong, Yoo-Seong, Balla, Anusha, Chun, Kwang-Hoon, Chung, Suk-Jae, Maeng, Han-Joo
Formato: Artigo
Lenguaje:Inglês
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6470842/
https://ncbi.nlm.nih.gov/pubmed/30845766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics11030108
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares