Pharmacokinetics of Procainamide and N-acetylprocainamide during Continuous Renal Replacement Therapy

Procainamide and its major metabolite, N-acetyl procainamide (NAPA), prolong the QTc interval and can promote potentially fatal ventricular arrhythmias. Excretion of procainamide and NAPA is reduced in patients with chronic kidney disease (CKD) resulting in drug accumulation and toxicity. The elimin...

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Bibliographic Details
Main Authors: Mohamed, Ahmed N., Abdelhady, Ahmed M., Spencer, Dustin, Sowinski, Kevin M., Tisdale, James E., Overholser, Brian R.
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3851309/
https://ncbi.nlm.nih.gov/pubmed/23562328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.ajkd.2013.02.358
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