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Pharmacokinetics of Procainamide and N-acetylprocainamide during Continuous Renal Replacement Therapy

Procainamide and its major metabolite, N-acetyl procainamide (NAPA), prolong the QTc interval and can promote potentially fatal ventricular arrhythmias. Excretion of procainamide and NAPA is reduced in patients with chronic kidney disease (CKD) resulting in drug accumulation and toxicity. The elimin...

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Bibliografske podrobnosti
Main Authors: Mohamed, Ahmed N., Abdelhady, Ahmed M., Spencer, Dustin, Sowinski, Kevin M., Tisdale, James E., Overholser, Brian R.
Format: Artigo
Jezik:Inglês
Izdano: 2013
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3851309/
https://ncbi.nlm.nih.gov/pubmed/23562328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.ajkd.2013.02.358
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