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Pharmacokinetics of Procainamide and N-acetylprocainamide during Continuous Renal Replacement Therapy
Procainamide and its major metabolite, N-acetyl procainamide (NAPA), prolong the QTc interval and can promote potentially fatal ventricular arrhythmias. Excretion of procainamide and NAPA is reduced in patients with chronic kidney disease (CKD) resulting in drug accumulation and toxicity. The elimin...
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| Asıl Yazarlar: | , , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2013
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3851309/ https://ncbi.nlm.nih.gov/pubmed/23562328 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.ajkd.2013.02.358 |
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