Physiologically-Based Pharmacokinetic Modeling for Drug-Drug Interactions of Procainamide and N-Acetylprocainamide with Cimetidine, an Inhibitor of rOCT2 and rMATE1, in Rats

Previous observations demonstrated that cimetidine decreased the clearance of procainamide (PA) and/or N-acetylprocainamide (NAPA; the primary metabolite of PA) resulting in the increased systemic exposure and the decrease of urinary excretion. Despite an abundance of in vitro and in vivo data regar...

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Bibliographic Details
Published in:Pharmaceutics
Main Authors: Jeong, Yoo-Seong, Balla, Anusha, Chun, Kwang-Hoon, Chung, Suk-Jae, Maeng, Han-Joo
Format: Artigo
Language:Inglês
Published: MDPI 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6470842/
https://ncbi.nlm.nih.gov/pubmed/30845766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics11030108
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