Simultaneous Determination of Procainamide and N-acetylprocainamide in Rat Plasma by Ultra-High-Pressure Liquid Chromatography Coupled with a Diode Array Detector and Its Application to a Pharmacokinetic Study in Rats

A simple, sensitive, and reliable reversed-phase, Ultra-High-Pressure Liquid Chromatography (UHPLC) coupled with a Diode Array Detector (DAD) method for the simultaneous determination of Procainamide (PA) and its major metabolite, N-acetylprocainamide (NAPA), in rat plasma was developed and validate...

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Main Authors: Anusha Balla, Kwan Hyung Cho, Yu Chul Kim, Han-Joo Maeng
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2018-03-01
Colecção:Pharmaceutics
Assuntos:
procainamide
N-acetylprocainamide
ultra-high-pressure liquid chromatography
rat
plasma
pharmacokinetics
Acesso em linha:http://www.mdpi.com/1999-4923/10/2/41
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