Procainamide, but not N-Acetylprocainamide, Induces Protein Free Radical Formation on Myeloperoxidase: A Potential Mechanism of Agranulocytosis

[Image: see text] Procainamide (PA) is a drug that is used to treat tachycardia in post-operative patients or for long term maintenance of cardiac arrythmias. Unfortunately, its use has also been associated with agranulocytosis. Here we have investigated the metabolism of PA by myeloperoxidase (MPO)...

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Bibliografiske detaljer
Main Authors: Siraki, Arno G., Deterding, Leesa J., Bonini, Marcelo G., Jiang, JinJie, Ehrenshaft, Marilyn, Tomer, Kenneth B., Mason, Ronald P.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2766841/
https://ncbi.nlm.nih.gov/pubmed/18489081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx700415b
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