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Aminoglutethimide-Induced Protein Free Radical Formation on Myeloperoxidase: A Potential Mechanism of Agranulocytosis

Aminoglutethimide (AG) is a first-generation aromatase inhibitor used for estrogen-dependent breast cancer. Unfortunately, its use has also been associated with agranulocytosis. We have investigated the metabolism of AG by myeloperoxidase (MPO) and the formation of an MPO protein free radical. We hy...

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Detalhes bibliográficos
Main Authors: Siraki, Arno G., Bonini, Marcelo G., Jiang, JinJie, Ehrenshaft, Marilyn, Mason, Ronald P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2073000/
https://ncbi.nlm.nih.gov/pubmed/17602675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx6003562
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