Small molecule nicotinamide N-methyltransferase inhibitor activates senescent muscle stem cells and improves regenerative capacity of aged skeletal muscle

Aging is accompanied by progressive declines in skeletal muscle mass and strength and impaired regenerative capacity, predisposing older adults to debilitating age-related muscle deteriorations and severe morbidity. Muscle stem cells (muSCs) that proliferate, differentiate to fusion-competent myobla...

Full description

Saved in:
Bibliographic Details
Published in:Biochem Pharmacol
Main Authors: Neelakantan, Harshini, Brightwell, Camille R., Graber, Ted G., Maroto, Rosario, Leo Wang, Hua-Yu, McHardy, Stanton F., Papaconstantinou, John, Fry, Christopher S., Watowich, Stanley J.
Format: Artigo
Language:Inglês
Published: 2019
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6469996/
https://ncbi.nlm.nih.gov/pubmed/30753815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2019.02.008
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items