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Combined nicotinamide N-methyltransferase inhibition and reduced-calorie diet normalizes body composition and enhances metabolic benefits in obese mice

Obesity is a large and growing global health problem with few effective therapies. The present study investigated metabolic and physiological benefits of nicotinamide N-methyltransferase inhibitor (NNMTi) treatment combined with a lean diet substitution in diet-induced obese mice. NNMTi treatment co...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Sampson, Catherine M., Dimet, Andrea L., Neelakantan, Harshini, Ogunseye, Kehinde O., Stevenson, Heather L., Hommel, Jonathan D., Watowich, Stanley J.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7952898/
https://ncbi.nlm.nih.gov/pubmed/33707534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-85051-6
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